Ammonia → 5-Bromo-4-fluoro-2-nitroaniline

HRID 408736

Reaktionsgleichung

Reaktionsgleichung von HRID 408736
[Br:1][C:2]1[CH:7]=[C:6](F)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][C:3]=1[F:12].[NH3:13]>CO>[Br:1][C:2]1[C:3]([F:12])=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:13])[CH:7]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 27362864-Bromo-2,5-difluoronitrobenzene

Produkt 1

HCID 669372515-Bromo-4-fluoro-2-nitroaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 1-bromo-2,5-difluoro-4-nitro-benzene (1.50 g, 6.30 mmol) and 7M ammonia in methanol (25 mL) was heated in a sealed tube at 60° C. for 15 h. The reaction mixture was transferred to a round bottom flask, washing the sealed tube with EtOAc. The reaction mixture was concentrated, and the crude material was used in the next step without further purification.

Aufarbeitung

  1. customThe reaction mixture was transferred to a round bottom flask
  2. washwashing the sealed tube with EtOAc
  3. concentrationThe reaction mixture was concentrated
  4. customthe crude material was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-58306cd599c14be59297b4ae57f9a0c7
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759345B2

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