Cyclopropanemethanamine → Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoate

HRID 408861Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 408861
[CH:1]1([CH2:4][NH2:5])[CH2:3][CH2:2]1.[N:6]([C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][CH:10]=1)=[C:7]=[O:8]>ClCCl>[CH:1]1([CH2:4][NH:5][C:7](=[O:8])[NH:6][C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][CH:10]=2)[CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 75646CyclopropanemethanamineHCID 589805Ethyl 4-isocyanatobenzoate

Produkt 1

HCID 3830959Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoateAusbeute 107,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To cyclopropylmethanamine (57.5 mmol, 4.99 ml, 4.09 g) in dichloromethane (40 mL) was added to ethyl 4-isocyanatobenzoate (52.3 mmol, 10 g) in dichloromethane (45 mL) and the reaction stirred overnight. The reaction was then concentrated under reduced pressure to give the title compound (14.7 g).

Aufarbeitung

  1. concentrationThe reaction was then concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a025eb4f1c524d379e0511ca45ef8992
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759352B2

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