HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Borane;tetrahydrofuran → Tert-butyl 3-hydroxy-1-(thiophen-3-yl)propylcarbamate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Borane;tetrahydrofuran | HCID 2723981 | — |
| Edukt | 3-((tert-Butoxycarbonyl)amino)-3-(thiophen-3-yl)propanoic acid | HCID 2764536 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | Tert-butyl 3-hydroxy-1-(thiophen-3-yl)propylcarbamate | HCID 59161739 | — |
Reaktionsschritte
To (±)-2-(tert-butoxycarbonylamino)-2-(thiophen-3-yl)propanoic acid (E4) in THF at 0° C. is added BH3-THF dropwise. The solution is allowed to warm to room temperature and stirred for an additional 2 hours. The solution is cooled to 0° C., quenched with AcOH (10%)/MeOH, and evaporated. Column chromatography (SiO2, EtOAc) gives pure tert-butyl 3-hydroxy-1-(thiophen-3-yl)propylcarbamate (E73A).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08759388B2 |
| Quelldatensatz | uspto-grants-2014_06 |
| ORD ID | ord-4bd74dcff9f34820961402aee4bb2610 |
| Quellennotiz | uspto-grants-2014_06 |