Potassium Hydroxide → HCID 18317887, Verbindung

HRID 409489Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 409489
[CH3:1][O:2][C:3]([C:5]1([C:10]([O:12]C)=[O:11])[CH2:9][CH2:8][CH2:7][CH2:6]1)=[O:4].[OH-].[K+]>CO>[CH3:1][O:2][C:3]([C:5]1([C:10]([OH:12])=[O:11])[CH2:9][CH2:8][CH2:7][CH2:6]1)=[O:4]

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 12609605Dimethyl cyclopentane-1,1-dicarboxylate

Produkt 1

HCID 18317887HCID 18317887, VerbindungAusbeute 100,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of cyclopentane-1,1-dicarboxylic acid dimethyl ester (4.0 g, 21.5 mmol) in MeOH (25 mL) is added potassium hydroxide (1.32 g, 23.7 mmol). The mixture is stirred at room temperature for 15 hours and concentrated under reduced pressure. To the obtained residue, aqueous 1M HCl (50 mL) is added and the solution is extracted with EtOAc. The organic layer is washed with H2O, dried over Na2SO4, and concentrated under reduced pressure to give cyclopentane-1,1-dicarboxylic acid methyl ester (3.72 g, quant.); TLC (dichloromethane/MeOH, 10:1) Rf 0.25.

Aufarbeitung

  1. concentrationconcentrated under reduced pressure
  2. additionTo the obtained residue, aqueous 1M HCl (50 mL) is added
  3. extractionthe solution is extracted with EtOAc
  4. washThe organic layer is washed with H2O
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-50936aa06d8045f590105a42f7386f23
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759365B2

Notizen zur Reaktion

Wird geladen…