Glyoxylic Acid → Alpha-Hydroxyhippuric acid

HRID 409617

Reaktionsgleichung

Reaktionsgleichung von HRID 409617
[C:1]([NH2:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]([OH:14])(=[O:13])[CH:11]=[O:12]>CC(C)=O>[C:1]([NH:9][CH:11]([OH:12])[C:10]([OH:14])=[O:13])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 760Glyoxylic AcidHCID 2331Benzamide

Produkt 1

HCID 450272Alpha-Hydroxyhippuric acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of commercially available benzamide 35 and glyoxylic acid 41 was heated at reflux in acetone to give pure N-benzoyl-2-hydroxyglycine 65 as a colourless solid in quantitative yield (Scheme 4.12). The 1H n.m.r. spectrum supported formation of the α-hydroxyglycine derivative 65 with the appearance of a methine (H2) doublet and broad amide (NH) doublet at δ 5.60 and δ 9.26 respectively. Spectroscopic data were in agreement with those reported in the literature.209

Aufarbeitung

  1. temperaturewas heated

Quellen und Nachweise

ORD-Eintrag
ord-a692eb16a5cb479e9636611ee822a749
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759480B2

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