Sodium Hydroxide → HCID 43566624, Verbindung

HRID 409931Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 409931
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]3[CH:13]=[CH:14][C:15]([C:17]([O:19]C)=[O:18])=[CH:16][C:11]=3[N:10]=[CH:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>CCO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]3[CH:13]=[CH:14][C:15]([C:17]([OH:19])=[O:18])=[CH:16][C:11]=3[N:10]=[CH:9]2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 59625812HCID 59625812, Verbindung

Produkt 1

HCID 43566624HCID 43566624, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 27e (0.18 g, 0.666 mmol) in EtOH (10 mL) was added 1N aqueous NaOH (2.5 mL, 2.5 mmol). The mixture was stirred at room temperature for 4 d. The solvent was evaporated and 1N aqueous HCl was added, followed by extraction with EtOAc. The organic layer was dried over MgSO4 and concentrated. The crude product 27f was purified by preparative reverse phase chromatography. MS m/z (M+H+) 257.1.

Aufarbeitung

  1. customThe solvent was evaporated
  2. addition1N aqueous HCl was added
  3. extractionfollowed by extraction with EtOAc
  4. dry with materialThe organic layer was dried over MgSO4
  5. concentrationconcentrated
  6. customThe crude product 27f was purified by preparative reverse phase chromatography

Quellen und Nachweise

ORD-Eintrag
ord-c6b53a84db784c378ac8c911c1827a93
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759533B2

Notizen zur Reaktion

Wird geladen…