HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Bromoaniline → N-(4-Bromophenyl)-2-(2,2-difluoroethoxy)-4-cyclopropylamino-5-amino-benzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Bromoaniline | HCID 7807 | — |
| Edukt | Cyclopropylamine | HCID 69828 | — |
| Edukt | 2,2-Difluoroethan-1-ol | HCID 136187 | — |
| Edukt | 2,4-Difluoro-5-nitrobenzoic acid | HCID 2782822 | — |
| Edukt | HCID 86669633 | HCID 86669633 | — |
| Katalysator | HCID 178506447 | HCID 178506447 | — |
| Produkt | N-(4-Bromophenyl)-2-(2,2-difluoroethoxy)-4-cyclopropylamino-5-amino-benzamide | HCID 86669632 | — |
Reaktionsschritte
The subtitle compound is prepared from N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-cyclopropylamino-5-nitro-benzamide (prepared from 2,4-difluoro-5-nitrobenzoic acid, cyclopropylamine, 4-bromoaniline and 2,2-difluoroethanol in analogy to the examples 1c, 6a, 1e) and RaNi/H2 in analogy to example 5c.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08759537B2 |
| Quelldatensatz | uspto-grants-2014_06 |
| ORD ID | ord-82de4134b99642ad9588ec0d3469cb1c |
| Quellennotiz | uspto-grants-2014_06 |