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Tetrahydrofuran → 2-[3-(1,3-Thiazol-5-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]propan-2-ol

HRID 410410
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 410410
[S:1]1[C:5]([C:6]2[CH:7]=[C:8]([CH:13]=[C:14]([NH:16][C:17]3[N:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[CH:19][N:18]=3)[CH:15]=2)C(OC)=O)=[CH:4][N:3]=[CH:2]1.[CH2:27]1COCC1.C[Mg]Cl.C([O:38][CH2:39][CH3:40])(=O)C>>[S:1]1[C:5]([C:6]2[CH:7]=[C:8]([C:39]([OH:38])([CH3:40])[CH3:27])[CH:13]=[C:14]([NH:16][C:17]3[N:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[CH:19][N:18]=3)[CH:15]=2)=[CH:4][N:3]=[CH:2]1
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Komponenten

5

Edukt 4

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 67262142Methyl 3-(1,3-thiazol-5-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}benzoateHCID 178418332HCID 178418332, Verbindung2×

Produkt 1

HCID 584564182-[3-(1,3-Thiazol-5-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]propan-2-olAusbeute 74 %

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a flask containing the product of Step 3 (254 mg, 0.67 mmol) was added THF (6.7 mL). The solution was cooled to 0° C. and then methylmagnesium chloride (3.0M in Et2O, 1.1 mL, 3.3 mmol) was added and the reaction was stirred for one hour. After one hour, more methylmagnesium chloride (3.0M in Et2O, 1.1 mL, 3.3 mmol) was added and the reaction was stirred for 30 minutes. The reaction was then diluted with ethyl acetate and carefully quenched with water and then diluted with water. The organic layer was separated, dried over magnesium sulfate, filtered and concentrated. Flash chromatography was used for purification to yield 2-[3-(1,3-thiazol-5-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]propan-2-ol (188 mg, 0.49 mmol, 74% yield). MS ESI: [M+H]+ m/z 381. 1H NMR (500 MHz, DMSO-d6) δ 10.26 (s, 1H), 9.07 (s, 1H), 8.82 (d, J=4.8, 1H), 8.20 (s, 1H), 8.03 (s, 1H), 7.79 (s, 1H), 7.45 (s, 1H), 7.28 (d, J=4.9, 1H), 5.12 (s, 1H), 1.46 (s, 6H).

Aufarbeitung

  1. waitAfter one hour
  2. stirringthe reaction was stirred for 30 minutes
  3. customcarefully quenched with water
  4. additiondiluted with water
  5. customThe organic layer was separated
  6. dry with materialdried over magnesium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customFlash chromatography was used for purification

Quellen und Nachweise

ORD-Eintrag
ord-2b9311c483d34fe5ad0f1ea119bc5e0a
Quelldatensatz
uspto-grants-2014_06
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08759366B2

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