2-Methoxyethylamine → Methyl 4-((2-methoxyethyl)amino)-3-nitrobenzoate

HRID 410902Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 410902
Cl[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[CH3:15][O:16][CH2:17][CH2:18][NH2:19]>CN(C=O)C>[CH3:9][O:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([NH:19][CH2:18][CH2:17][O:16][CH3:15])=[C:3]([N+:12]([O-:14])=[O:13])[CH:4]=1

Komponenten

4

Edukt 2

HCID 80182-MethoxyethylamineHCID 735797Methyl 4-chloro-3-nitrobenzoate

Produkt 1

HCID 67335214Methyl 4-((2-methoxyethyl)amino)-3-nitrobenzoateAusbeute 81,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4-(2-Methoxy-ethylamino)-3-nitro-benzoic acid methyl ester (960.0 mg) was prepared by following General Procedure A starting from methyl 4-chloro-3-nitrobenzoate (1.0 g) and 2-methoxy-ethylamine (413.0 mg) in DMF (10.0 mL). The crude product was used in the next step without further purification.

Aufarbeitung

  1. customThe crude product was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-2d6bd3c84a2c4c2eb409de875b20f45e
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759535B2

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