(4-Methylamino-3-nitro-benzoylamino)-acetic acid tert-butyl ester → (4-Methylamino-3-nitro-benzoylamino)-acetic acid

HRID 411051

Reaktionsgleichung

Reaktionsgleichung von HRID 411051
C([O:5][C:6](=[O:22])[CH2:7][NH:8][C:9](=[O:21])[C:10]1[CH:15]=[CH:14][C:13]([NH:16][CH3:17])=[C:12]([N+:18]([O-:20])=[O:19])[CH:11]=1)(C)(C)C>Cl.O1CCOCC1.C(Cl)Cl>[CH3:17][NH:16][C:13]1[CH:14]=[CH:15][C:10]([C:9]([NH:8][CH2:7][C:6]([OH:22])=[O:5])=[O:21])=[CH:11][C:12]=1[N+:18]([O-:20])=[O:19]

Komponenten

4

Edukt 1

HCID 67332520(4-Methylamino-3-nitro-benzoylamino)-acetic acid tert-butyl ester

Produkt 1

HCID 67334647(4-Methylamino-3-nitro-benzoylamino)-acetic acidAusbeute 81,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 204431481,4-Dioxane hydrochlorideLösungsmittel

Versuchsvorschrift

(4-Methylamino-3-nitro-benzoylamino)-acetic acid (800 mg) was prepared starting from (4-methylamino-3-nitro-benzoylamino)-acetic acid tert-butyl ester (1.2 g) in 4 M HCl-dioxane (2 mL) and DCM (2 mL). The reaction was stirred at room temperature for 8 h. The solvent was evaporated to isolate pure compound without any further purification.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customto isolate pure compound
  3. customwithout any further purification

Quellen und Nachweise

ORD-Eintrag
ord-040cee8d28ca45deb8dd242cb4abb8bb
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759535B2

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