2-methylpropyl (2S)-2-aminopropanoate → N-[(3-phenyl-1,2,4thiadiazol-5yl)acetyl]alanine Iso-butyl Ester

HRID 411491Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 411491
[C:1]1([C:7]2[N:11]=[C:10]([CH2:12][C:13]([OH:15])=O)[S:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]([O:20][C:21](=[O:25])[C@H:22]([CH3:24])[NH2:23])[CH:17]([CH3:19])[CH3:18]>>[CH2:16]([O:20][C:21](=[O:25])[C@H:22]([CH3:24])[NH:23][C:13](=[O:15])[CH2:12][C:10]1[S:9][N:8]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:11]=1)[CH:17]([CH3:19])[CH3:18]

Komponenten

3

Edukt 2

HCID 137435562-methylpropyl (2S)-2-aminopropanoateHCID 224921842-(3-Phenyl-1,2,4-thiadiazol-5-yl)acetic acid

Produkt 1

HCID 22894976N-[(3-phenyl-1,2,4thiadiazol-5yl)acetyl]alanine Iso-butyl Ester

Versuchsvorschrift

Following General Procedure BI above, and using (3-phenyl-1,2,4-thiadiazol-5-yl)acetic acid (CAS #90771-06-5) and alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Aufarbeitung

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Quellen und Nachweise

ORD-Eintrag
ord-5cf2a18643ec4561a03fdebcc6b3cfab
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06559141B2

Notizen zur Reaktion

Wird geladen…