HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Cyanide → (4R *,5R*)-5-(4-chloro-3-trifluoromethyl-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Cyanide | HCID 8929 | — |
| Edukt | 4-Chloro-3-(trifluoromethyl)benzaldehyde | HCID 118642 | — |
| Edukt | Tosylmethyl isocyanide | HCID 161915 | — |
| Produkt | (4R *,5R*)-5-(4-chloro-3-trifluoromethyl-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole | HCID 69556945 | — |
Reaktionsschritte
In a manner analogous to Preparation 1, 4-chloro-3-(trifluoromethyl)benzaldehyde (0.31 g, 1.47 mmol), tosylmethylisocyanide (0.27 g, 1.40 mmol) and NaCN (6.9 mg, 0.14 mmol) gave the desired compound as a tan solid. MS(ES+) m/z 404.5 (M+H+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06559172B1 |
| Quelldatensatz | uspto-grants-2003_05 |
| ORD ID | ord-2062fb24d3e14162a441c15b1be6598e |
| Quellennotiz | uspto-grants-2003_05 |