Hydrazine → HCID 178489814, Verbindung

HRID 411699

Reaktionsgleichung

Reaktionsgleichung von HRID 411699
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9](=O)[CH2:10][C:11]#[N:12])[CH:6]=[CH:7][CH:8]=1.[NH2:14][NH2:15]>CCO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]([NH2:12])[NH:14][N:15]=2)[CH:6]=[CH:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 5847163-(3-Methoxyphenyl)-3-oxopropanenitrile

Produkt 1

HCID 178489814HCID 178489814, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

3-(3-Methoxy-phenyl)-3-oxo-propionitrile (2.0202 gms.) is then suspended in 55 mL of anhydrous EtOH. This suspension is treated with 0.73 mL of anhydrous hydrazine and subsequently heated to refluxing temperature for 1 day. The reaction mixture is concentrated in vacuo. The residue is then triturated with isopropanol to precipitate out the 5-(3-methoxy-phenyl)-2H-pyrazol-3-ylamine as a white solid.

Aufarbeitung

  1. temperaturesubsequently heated
  2. temperatureto refluxing temperature for 1 day
  3. concentrationThe reaction mixture is concentrated in vacuo
  4. customThe residue is then triturated with isopropanol
  5. customto precipitate out the 5-(3-methoxy-phenyl)-2H-pyrazol-3-ylamine as a white solid

Quellen und Nachweise

ORD-Eintrag
ord-7a04ae81653d45c083f1248453501ccf
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06559173B1

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