3-Amino-5-phenylpyrazole → HCID 178517310, Verbindung

HRID 411728Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 411728
O/[CH:2]=[C:3]1\[C:4](=[O:13])[NH:5][C:6]2[C:11]\1=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=2.O/C=C1\C(=O)NC2C\1=CC=CC=2.[C:26]1([C:32]2[NH:36][N:35]=[C:34]([NH2:37])[CH:33]=2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.NC1C=CNN=1>O1CCCC1>[F:12][C:8]1[CH:7]=[C:6]2[C:11]([C:3](=[CH:2][NH:37][C:34]3[CH:33]=[C:32]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[NH:36][N:35]=3)[C:4](=[O:13])[NH:5]2)=[CH:10][CH:9]=1

Komponenten

6

Edukt 4

HCID 1366553-Amino-5-phenylpyrazole2×HCID 178418806HCID 178418806, VerbindungHCID 178517101HCID 178517101, VerbindungHCID 178517312(3Z)-6-fluoro-3-(hydroxymethylidene)-1H-indol-2-one2×

Produkt 1

HCID 178517310HCID 178517310, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-6-fluoro-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one and 5-phenyl-1H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-6-fluoro-1,3-dihydro-indol-2-one (0.033 gms.) is reacted with 0.065 gms. 5-phenyl-1H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (0.88 mL) to afford the named compound in the amount of 0.0417 gms.

Aufarbeitung

  1. customThe named compound is prepared
  2. customin the reaction of Example 1
  3. customto afford the named compound in the amount of 0.0417 gms

Quellen und Nachweise

ORD-Eintrag
ord-6f318ec8221c4b08903fd9d8a3799992
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06559173B1

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