Ethyl stearate → Palmitic Acid

HRID 411753

Reaktionsgleichung

Reaktionsgleichung von HRID 411753
[C:1]([O:20]CC)(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]CC.C(O)(=O)CCCCCCC/C=C\CCCCCCCC.CCOC([C@@H](N[C@@H]1C(=O)N2N(CCC[C@H]2C(O)=O)CCC1)CCC1C=CC=CC=1)=O.O>>[C:1]([OH:20])(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Komponenten

4

Edukt 3

HCID 8122Ethyl stearateHCID 56329Cilazapril MonohydrateHCID 445639Oleic Acid

Produkt 1

HCID 985Palmitic Acid

Reaktionsbedingungen

Temperatur
100 fahrenheit

Versuchsvorschrift

1.500 Grams of ethyl stearate, 6.25 mg of PGE 2 and 62.5 mg of oleic acid were placed in a Pyrex test tube and heated to about 100° F. on a hot plate with periodic agitation. The mixture rapidly melted to afford a clear solution. A standard laboratory micropipette (Justor 1100BG manufactured by Nichiryo and available from Sigma, St. Louis, Mo. USA with volume dispensed adjustable from 10.0 to 100.0 microliters; and Sigma pipette tips—catalog #B-6429) was repeatedly dipped into this solution and aspirated with the volume set at 37 microliters. The solution rapidly solidified at ambient room temperature (71° F.) and the resultant suppository was removed by pressing a paper clip into the tip of the pipette. Approximately 100 suppositories were made in a two hour period using this method. Subsequent weighing showed that 96% of the suppositories weighed 31±0.5 mgs. Similar results were obtained when palmitic acid was substituted for oleic acid.

Aufarbeitung

  1. customto afford a clear solution
  2. customrapidly solidified at ambient room temperature
  3. custom(71° F.)
  4. customthe resultant suppository was removed
  5. customSimilar results

Quellen und Nachweise

ORD-Eintrag
ord-fb84677b03e34e9d8da1d619380d74b0
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06559184B2

Verknüpfte Notizen

Wird geladen…