Sodium Bicarbonate → HCID 9851675, Verbindung

HRID 411773Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 411773
F[C:2](F)(F)[C:3]([OH:5])=[O:4].[CH3:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:18]2[C:19](=[O:47])[N:20]([CH2:37][O:38][C:39]([CH:41]3[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]3)=[O:40])[C:21](=[O:36])[C:22]=2[C:23]2[C:31]3[C:26](=[CH:27][C:28]([N+:32]([O-:34])=[O:33])=[CH:29][CH:30]=3)[N:25]([CH3:35])[CH:24]=2)=[CH:10]1.C([O-])(O)=O.[Na+]>C(OCC)(=O)C>[C:3]([OH:5])(=[O:4])[CH3:2].[CH3:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:18]2[C:19](=[O:47])[N:20]([CH2:37][O:38][C:39]([CH:41]3[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]3)=[O:40])[C:21](=[O:36])[C:22]=2[C:23]2[C:31]3[C:26](=[CH:27][C:28]([N+:32]([O-:34])=[O:33])=[CH:29][CH:30]=3)[N:25]([CH3:35])[CH:24]=2)=[CH:10]1

Komponenten

4

Edukt 2

HCID 516892Sodium BicarbonateHCID 69945384HCID 69945384, Verbindung

Produkt 1

HCID 9851675HCID 9851675, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Piperidine-4-carboxylic acid 3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-pyrrol-1-ylmethyl ester trifluoroacetate, prepared as in example 8a above, was dissolved in ethyl acetate. The resulting solution was neutralized with cold saturated NaHCO3. The ethyl acetate layer was concentrated and slurried in H2O and acidified with excess HOAc and lyophilized to give the desired product (yield—97%).

Aufarbeitung

  1. concentrationThe ethyl acetate layer was concentrated and slurried in H2O

Quellen und Nachweise

ORD-Eintrag
ord-b0edc6bffe5648f4be3317a0bdda8d7b
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06559164B1

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