3-Chlorobenzaldehyde → 2-m-Chlorophenyl-3-(3-trifluoromethyl-4-fluorophenyl)-5-ethyl oxazolidine

HRID 4122

Reaktionsgleichung

Reaktionsgleichung von HRID 4122
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[F:10][C:11]([F:26])([F:25])[C:12]1[CH:13]=[C:14]([NH:19][CH2:20][CH:21](O)[CH2:22][CH3:23])[CH:15]=[CH:16][C:17]=1[F:18]>CS(O)(=O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]2[N:19]([C:14]3[CH:15]=[CH:16][C:17]([F:18])=[C:12]([C:11]([F:26])([F:10])[F:25])[CH:13]=3)[CH2:20][CH:21]([CH2:22][CH3:23])[O:6]2)[CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 114773-ChlorobenzaldehydeHCID 201526711-(3-Trifluoromethyl-4-fluorophenylamino)-2-butanol

Produkt 1

HCID 201526702-m-Chlorophenyl-3-(3-trifluoromethyl-4-fluorophenyl)-5-ethyl oxazolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6395Methanesulfonic AcidKatalysator

Versuchsvorschrift

Meta-chlorobenzaldehyde (2.3 g, 0.016 mole) was combined with 5 g of 1-(3-trifluoromethyl-4-fluorophenylamino)-2-butanol and 3 drops of methane sulfonic acid was added. The mixture was heated on the steam bath for about one hour and stripped on the rotary evaporator. The product, a sticky, thick liquid, was characterized by IR and NMR.

Aufarbeitung

  1. additionwas added
  2. temperatureThe mixture was heated on the steam bath for about one hour
  3. customstripped on the rotary evaporator

Quellen und Nachweise

ORD-Eintrag
ord-2606b9cbf440416d8f3e63a1500dbed7
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04723986

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