StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Sodium Hydroxide → (R)-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino]-2-hydroxypropionic Acid

HRID 412432
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 412432
C([O:3][C:4](=[O:48])[C@H:5]([OH:47])[CH2:6][NH:7][C:8](=[O:46])[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][N:16]([C:34]2[CH:39]=[CH:38][C:37]([CH:40]3[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]3)=[CH:36][CH:35]=2)[C:17]([NH:19][C:20]2[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[C:22]([C:30]([F:33])([F:32])[F:31])[CH:21]=2)=[O:18])=[CH:11][CH:10]=1)C.[OH-].[Na+]>C(O)C>[F:27][C:26]([F:28])([F:29])[C:24]1[CH:25]=[C:20]([NH:19][C:17](=[O:18])[N:16]([CH2:15][C:12]2[CH:11]=[CH:10][C:9]([C:8]([NH:7][CH2:6][C@@H:5]([OH:47])[C:4]([OH:48])=[O:3])=[O:46])=[CH:14][CH:13]=2)[C:34]2[CH:39]=[CH:38][C:37]([CH:40]3[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]3)=[CH:36][CH:35]=2)[CH:21]=[C:22]([C:30]([F:32])([F:33])[F:31])[CH:23]=1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 86586059(R)-3-(4-[3-(3,5-Bis(trifluoromethyl)phenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino]-2-hydroxypropionic acid ethyl ester

Produkt 1

HCID 10168450(R)-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino]-2-hydroxypropionic AcidAusbeute 84,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702
Ethanol
Lösungsmittel

Versuchsvorschrift

(R)-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)-1-(4-cyclohexylphenyl)ureidomethyl] benzoyl-amino}-2-hydroxypropionic acid ethyl ester (0.26 g, 0.38 mmol) was dissolved in ethanol (96%, 15 mL) and added sodium hydroxide (4 N, 0.57 mL, 2.3 mmol). After stirring at 25 OC for 1 hour the mixture was evaporated in vacuo, and the residue was added water (30 mL) and acidified with hydrochloric acid (4 N, 0.62 mL). The aqueous phase was extracted twice with ethyl acetate (25 mL and 10 mL) and the combined organic phases were washed with saturated sodium chloride:water (1:1), dried (magnesium sulphate) and concentrated in vacuo to afford 0.21 g of the title compound.

Aufarbeitung

  1. customwas evaporated in vacuo
  2. additionthe residue was added water (30 mL)
  3. extractionThe aqueous phase was extracted twice with ethyl acetate (25 mL and 10 mL)
  4. washthe combined organic phases were washed with saturated sodium chloride:water (1:1)
  5. dry with materialdried (magnesium sulphate)
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-bf21fbdb03c944d68e3d5bf566b137f5
Quelldatensatz
uspto-grants-2003_05
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US06562807B2

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion