Hydrogen Bromide → 1,2,3,4-Tetrahydroisoquinolin-6-ol hydrobromide
Reaktionsgleichung
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2.[BrH:13]>>[BrH:13].[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2Komponenten
3
Versuchsvorschrift
6-Methoxy-1,2,3,4-tetrahydroisoquinoline (2.89 g) was dissolved in 48% aqueous hydrogen bromide solution (70 ml) and the mixture was refluxed for 2 hours. The solvent was evaporated and to the obtained residue were added ethanol and diethyl ether. The mixture was filtrated and dried under reduced pressure to give the title compound (3.93 g).
Aufarbeitung
- temperaturethe mixture was refluxed for 2 hours
- customThe solvent was evaporated and to the obtained residue
- additionwere added ethanol and diethyl ether
- filtrationThe mixture was filtrated
- customdried under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-45378efb71f6493387a5248cd1d3c7af
- Quelldatensatz
- uspto-grants-2003_05
- Patentnummer
- US06562828B1
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