Hydrogen Bromide → 2,3,4,5-tetrahydro-1H-2-benzazepin-8-ol hydrobromide

HRID 412595Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 412595
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[CH:13]=1.[BrH:14]>>[BrH:14].[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[CH:13]=1

Komponenten

3

Edukt 2

HCID 260Hydrogen BromideHCID 154969548-Methoxy-2,3,4,5-tetrahydro-1H-benzo(c)azepine

Produkt 1

HCID 114479102,3,4,5-tetrahydro-1H-2-benzazepin-8-ol hydrobromide

Versuchsvorschrift

8-Methoxy-2,3,4,5-tetrahydro-1H-benz[c]azepine (3.65 g) was dissolved in 48% aqueous hydrogen bromide solution (36 ml) and the mixture was refluxed for 2 hours. The solvent was evaporated and ethanol and diethyl ether were added to the obtained residue. The mixture was filtrated and dried under reduced pressure to give the title compound (4.56 g).

Aufarbeitung

  1. temperaturethe mixture was refluxed for 2 hours
  2. customThe solvent was evaporated
  3. additionethanol and diethyl ether were added to the obtained residue
  4. filtrationThe mixture was filtrated
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-949b71e773254f5188db2f623d3f8843
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06562828B1

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