1-(Pyridin-4-yl)piperidine-4-carbamic acid benzyl ester → 1-(Pyridin-4-yl)piperidin-4-amine

HRID 412623Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 412623
C(OC(=O)[NH:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)[CH2:13][CH2:12]1)C1C=CC=CC=1>C(O)C.[C].[Pd]>[NH2:10][CH:11]1[CH2:12][CH2:13][N:14]([C:17]2[CH:18]=[CH:19][N:20]=[CH:21][CH:22]=2)[CH2:15][CH2:16]1

Komponenten

4

Edukt 1

HCID 600641081-(Pyridin-4-yl)piperidine-4-carbamic acid benzyl ester

Produkt 1

HCID 189186081-(Pyridin-4-yl)piperidin-4-amineAusbeute 99,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

1-(Pyridin-4-yl)piperidine-4-carbamic acid benzyl ester (9.46 g) was hydrogenated using 7.5% palladium carbon (3.57 g) in ethanol (95 ml) solution at 3 atm over 3 hours. After completion of the reaction, the reaction mixture was filtered through celite, and the solvent was evaporated and the residue was dried under reduced pressure to give the title compound (5.38 g).

Aufarbeitung

  1. customover 3 hours
  2. customAfter completion of the reaction
  3. filtrationthe reaction mixture was filtered through celite
  4. customthe solvent was evaporated
  5. customthe residue was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8d081c17604143c885296a33b2179a5f
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06562828B1

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