Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Gamma-Aminobutyric Acid | HCID 119 | — |
| Edukt | Phosphorus trichloride | HCID 24387 | — |
| Edukt | Phosphorous acid | HCID 107909 | — |
| Produkt | Alendronic Acid | HCID 2088 | — |
Reaktionsschritte
The mixture of 5 eq. phosphorous acid, 4-aminobutyric acid and morpholine. HCl is melted together until uniform solution is formed. The reaction mixture is cooled to about 70° C. and 2 eq. of PCl3 are carefully added. The mixture is heated for about 5.5 hours before the reaction mixture is hydrolyzed in aqueous acid at about 80° C. and alendronate is isolated from an ethanolic solution.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06562974B2 |
|---|
| Quelldatensatz | uspto-grants-2003_05 |
|---|
| ORD ID | ord-b3a0f7fd2bd7403f9357ce99aee0cb71 |
|---|
| Quellennotiz | uspto-grants-2003_05 |
|---|
