Potassium Iodide → HCID 18538872, Verbindung

Temperatur

80 °C

4-(5-Methyl-1,3,4-thiadiazol-2-ylthio)piperidine trifluoroacetate (59 mg, 0.18 mmol) was dissolved in dry acetonitrile (1.5 mL). To the solution were added 1-acetyl-N-(3-chlorophenyl)-N-(3-chloropropyl)-4-piperidinecarboxamide (50 mg, 0.14 mmol), potassium carbonate (77 mg, 0.56 mmol) and potassium iodide (23 mg, 0.14 mmol), and the mixture was stirred at 80° C. for 5 hours. The mixture was cooled to room temperature, and to the mixture was added saturated sodium chloride solution (3 mL). The mixture was extracted three times with ethyl acetate (2 mL). The extracts were combined and concentrated under reduced pressure. The concentrate was purified by using HPLC to give the titled compound as a colorless oily substance (32.2 mg, 28%).

1. temperatureThe mixture was cooled to room temperature
2. extractionThe mixture was extracted three times with ethyl acetate (2 mL)
3. concentrationconcentrated under reduced pressure
4. customThe concentrate was purified

ORD-Eintrag

ord-2ebd06ffe6e7402898b28e7a1016bd76

Quelldatensatz

uspto-grants-2003_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06562978B1