Benzyl Bromide → 1-benzyl-1H-pyrazole-3-carbaldehyde
Reaktionsgleichung
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:9]1[CH:13]=[CH:12][C:11]([CH:14]=[O:15])=[N:10]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:1]([N:9]1[CH:13]=[CH:12][C:11]([CH:14]=[O:15])=[N:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of benzyl bromide (0.29 g) in N,N-dimethylformamide (9 ml) was added 1H-pyrazole-3-carboxaldehyde (0.15 g) and potassium carbonate (0.24 g). The mixture was stirred at room temperature for 24 hours, silica gel was added, the solvent removed by evaporation and the crude material purified by chromatography (isohexane:ether, 2:1) to give the product as an oil (0.18 g).
Aufarbeitung
- additionsilica gel was added
- customthe solvent removed by evaporation
- customthe crude material purified by chromatography (isohexane:ether, 2:1)
Quellen und Nachweise
- ORD-Eintrag
- ord-6d33378c29d04b489b7fbd4671e4aa97
- Quelldatensatz
- uspto-grants-2003_05
- Patentnummer
- US06566376B1
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