Phosgene → 10-Methoxy-5H-dibenz(b,f)azepine-5-carbonyl chloride

HRID 41345

Reaktionsgleichung

Reaktionsgleichung von HRID 41345
C1C=CC2N(C(N)=O)C3C=CC=CC=3C(=O)CC=2C=1.[CH3:20][O:21][C:22]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[NH:26][C:25]2[CH:33]=[CH:34][CH:35]=[CH:36][C:24]=2[CH:23]=1.[C:37](Cl)([Cl:39])=[O:38]>>[CH3:20][O:21][C:22]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[N:26]([C:37]([Cl:39])=[O:38])[C:25]2[CH:33]=[CH:34][CH:35]=[CH:36][C:24]=2[CH:23]=1

Komponenten

4

Edukt 3

HCID 6371PhosgeneHCID 34312Oxcarbazepine2×HCID 7842410-Methoxyiminostilbene

Produkt 1

HCID 1605008110-Methoxy-5H-dibenz(b,f)azepine-5-carbonyl chloride

Versuchsvorschrift

U.S. Pat. No. 3,642,775 assigned to Ciba-Geigy Corporation, claims Oxcarbazepine specifically and discloses the process for the preparation of Oxcarbazepine, wherein 10-methoxy-5H-dibenz[b,f]azepine is reacted with phosgene gas to give 10-methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride and ammonolysis of the resultant compound to give the amide followed by hydrolysis to give Oxcarbazepine.

Quellen und Nachweise

ORD-Eintrag
ord-60bf5f9e5dc041ce8cc30181f4c613f9
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08530647B2

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