p-Toluenesulfonic acid → 3-(3,4-Dimethoxyphenyl)-2-propenal

Temperatur

95 °C

A solution of 3,4-dimethoxyphenylpropane (1 g) in 40 mL of dry dioxane was placed in 100 ml round bottom flask. To this was added a catalytic amount of para-toluenesulphonic acid (0.04 to 0.1 g and 4.5 g of DDQ and finally started refluxing the mixture at 50 to 140° C. for 7 to 16 hrs. The mixture was cooled and the precipitated DDQH2 was filtered and further washed with chloroform. The filtrate and washings were combined and evaporated under reduced pressure. The product was taken in ether (50 ml) and the ether layer was washed with aqueous NaOH (15%, 2×10 ml). The combined aqueous layers are further extracted with ether (3×10 ml). The ether layers were combined and washed with saturated sodium chloride (3×10 ml), dried over anhydrous sodium sulphate and filtered. The solvent was removed to afford a crude yellow liquid which was loaded on silica gel column and the column was eluted with hexane (40-50 ml) and then with an increasing amount of hexane/ethyl acetate (9:1 to 1:9). The fractions were monitored on TLC plate and the desired fractions were combined and solvent was removed under vacuum to afford 3,4-dimethoxycinnamaldehyde in 79% yield as a yellow solid; mp 74-77° C. ; 1H NMR δ 9.67 (1H, d, H-3′), 7.43 (1H, d, H-1′), 7.15 (1H, d, H-5), 7.08 (1H, s, H-3), 6.91 (1H, d, H-3), 6.61 (1H, dd, H-2′), 3.94 (s, 3H, 3-OCH3), 3.93 (s, 3H, 4-OCH3). The remaining physical and spectral data was found similar as reported.

1. temperatureThe mixture was cooled
2. filtrationthe precipitated DDQH2 was filtered
3. washfurther washed with chloroform
4. customevaporated under reduced pressure
5. washthe ether layer was washed with aqueous NaOH (15%, 2×10 ml)
6. extractionThe combined aqueous layers are further extracted with ether (3×10 ml)
7. washwashed with saturated sodium chloride (3×10 ml)
8. dry with materialdried over anhydrous sodium sulphate
9. filtrationfiltered
10. customThe solvent was removed
11. customto afford a crude yellow liquid which
12. washthe column was eluted with hexane (40-50 ml)
13. customsolvent was removed under vacuum

ORD-Eintrag

ord-825045592d484aea94bf1f32310fc8fd

Quelldatensatz

uspto-grants-2003_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06566557B2