Methyl acetoacetate → HCID 178500546, Verbindung

HRID 414018

Reaktionsgleichung

Reaktionsgleichung von HRID 414018
[C:1]([O:7][CH3:8])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[F:9][C:10]([F:14])([F:13])[C:11]#[N:12]>CC(C)([O-])C.[K+]>[C:3]([C:2](=[C:11]([NH2:12])[C:10]([F:14])([F:13])[F:9])[C:1]([O:7][CH3:8])=[O:6])(=[O:4])[CH3:5]

Komponenten

4

Edukt 2

HCID 7757Methyl acetoacetateHCID 67710Trifluoroacetonitrile

Produkt 1

HCID 178500546HCID 178500546, VerbindungAusbeute 66 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23665647Potassium tert-butoxideKatalysator

Versuchsvorschrift

To a 1 liter, four-necked flask equipped with nitrogen inlet, thermometer, and mechanical stirrer was charged 499.74 g (490 ml, 3.84 mol) of methyl acetoacetate and 12.9 g (0.115 mol) of potassium t-butoxide. The resulting mixture was stirred while 391 g (4.04 mol) of trifluoroacetonitrile was added. The reaction mixture was washed with hexane and the resulting solid was dried in vacuo affording 535 g (62%) of the enamine as a yellow solid; mp 63°-65° C.

Aufarbeitung

  1. customTo a 1 liter, four-necked flask equipped with nitrogen inlet
  2. additionwas added
  3. washThe reaction mixture was washed with hexane
  4. customthe resulting solid was dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8428274974d4438cab1e0d2f94ed7c81
Quelldatensatz
uspto-grants-1988_12
Patentnummer
US04789395

Verknüpfte Notizen

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