Formamide → N-Formyl-L-phenylalanine
Reaktionsgleichung
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH:13](N)=[O:14]>>[CH:13]([NH:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:14]Komponenten
3
Versuchsvorschrift
Under a nitrogen atmosphere, a slurry of 1.65 gm (10 mmol) phenylalanine in 4.0 ml (100 mmol) formamide was heated at 90° C. for 45 minutes. Examination of the resulting homogeneous solution by proton NMR showed an 85% conversion of the phenylalanine to its N-formyl derivative.
Quellen und Nachweise
- ORD-Eintrag
- ord-698f8654597746aebff6e872ea39ebfe
- Quelldatensatz
- uspto-grants-1988_12
- Patentnummer
- US04789757
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