HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Carbonate → 8-{[(Aminocarbonyl)oxy]methyl}-4,7-dihydroxy-1,1a,2,8,8a,8b-hexahydro-6-[(tert-butoxycarbonyl)azo]-8a-methoxy-5-methyl-azirino[2',3':3,4]pyrrolo[1,2-a]indole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | Mitomycin A | HCID 19972 | — |
| Edukt | tert-Butyl carbazate | HCID 70091 | — |
| Produkt | 8-{[(Aminocarbonyl)oxy]methyl}-4,7-dihydroxy-1,1a,2,8,8a,8b-hexahydro-6-[(tert-butoxycarbonyl)azo]-8a-methoxy-5-methyl-azirino[2',3':3,4]pyrrolo[1,2-a]indole | HCID 136342836 | 42,9% |
Reaktionsschritte
In a similar manner to that described in Example 17, mitomycin A (250 mg), tert-butoxycarbonylhydrazine (284 mg) and potassium carbonate (150 mg) are treated to obtain the desired product (138 mg) with a yield of 42.7%.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04791113 |
| Quelldatensatz | uspto-grants-1988_12 |
| ORD ID | ord-cfb506ab53ef4a579ed697997d7b5559 |
| Quellennotiz | uspto-grants-1988_12 |