Pyrrolidine → 2-(Pyrrolidin-1-ylmethyl)benzenesulfonamide

HRID 4143Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 4143
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH2:12])(=[O:11])=[O:10].[NH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1>C(#N)C>[N:13]1([CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[S:9]([NH2:12])(=[O:11])=[O:10])[CH2:17][CH2:16][CH2:15][CH2:14]1

Komponenten

4

Edukt 2

HCID 31268PyrrolidineHCID 133646272-(Chloromethyl)benzenesulfonamide

Produkt 1

HCID 133646292-(Pyrrolidin-1-ylmethyl)benzenesulfonamideAusbeute 92,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of 2-(chloromethyl)benzenesulfonamide (2.00 g, 10 mmol) in acetonitrile (20 ml) was contacted with pyrrolidine (1.6 ml, 20 mmol). After 1.0 hr at ambient temperature, the volatiles were removed under vacuum and the residue was treated with water (40 ml) and chilled. The resulting solid was pulverized, filtered, and dried to give 2.23 g of white solid, m.p. 110°-112°.

Aufarbeitung

  1. customthe volatiles were removed under vacuum
  2. additionthe residue was treated with water (40 ml)
  3. temperaturechilled
  4. filtrationfiltered
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-eab0fe71e0cc43c3893df4095261d255
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04723990

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