Olprinone → 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

HRID 414314

Reaktionsgleichung

Reaktionsgleichung von HRID 414314
[CH3:1][C:2]1[NH:7][C:6](=[O:8])[C:5]([C:9]#[N:10])=[CH:4][C:3]=1[C:11]1[CH:12]=[CH:13][C:14]2[N:15]([CH:17]=[CH:18][N:19]=2)[CH:16]=1.[OH2:20].N>S(=O)(=O)(O)O>[CH3:1][C:2]1[NH:7][C:6](=[O:8])[C:5]([C:9]([NH2:10])=[O:20])=[CH:4][C:3]=1[C:11]1[CH:12]=[CH:13][C:14]2[N:15]([CH:17]=[CH:18][N:19]=2)[CH:16]=1

Komponenten

4

Edukt 2

HCID 4593OlprinoneHCID 12896473Azane;hydrate

Produkt 1

HCID 138523295-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

In 15 ml of conc. sulfuric acid, 3 g of 1,2-dihydro-6-methyl-5-(imidazo[1,2-a]pyridin-6-yl)-2-oxo-3-pyridinecarbonitrile was stirred at 90° C. for 40 minutes. After cooling, the reaction mixture was poured into ice and conc. ammonia water was added thereto to render the mixture alkaline. Crystals prepcipitated were taken by filtration. After washing with water and drying, the crystals were recrystallized from N,N-dimethylformamide to obtain 2.5 g of 1,2-dihydro-6-methyl-5-(imidazo[1,2-a]pyridin-6-yl)-2-oxo-3-pyridinecarboxamide.

Aufarbeitung

  1. temperatureAfter cooling
  2. additionwas added
  3. filtrationCrystals prepcipitated were taken by filtration
  4. washAfter washing with water
  5. customdrying
  6. customthe crystals were recrystallized from N,N-dimethylformamide

Quellen und Nachweise

ORD-Eintrag
ord-675da39d20b347178dc5f484a9c07cb9
Quelldatensatz
uspto-grants-1988_12
Patentnummer
US04791202

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