Pyrrolidine → HCID 21282412, Verbindung

Reaktionsgleichung

[C:1]([O:7][CH3:8])(=[O:6])/[CH:2]=[CH:3]/[CH2:4][CH3:5].[NH:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1>>[N:9]1([CH:3]([CH2:4][CH3:5])[CH2:2][C:1]([O:7][CH3:8])=[O:6])[CH2:13][CH2:12][CH2:11][CH2:10]1

Komponenten

Edukt 2

HCID 31268Pyrrolidine

HCID 5364718Methyl 2-pentenoate

Produkt 1

HCID 21282412HCID 21282412, Verbindung

Reaktionsbedingungen

Temperatur: 100 °C

Versuchsvorschrift

A mixture of 171 g of methyl 2-trans-pentenoate and 106.5 g of pyrrolidine was heated for 20 hours at 100° C. After distillation over a Vigreux column, 198.7 g (72% of theory) of methyl 3-pyrrolidinovalerate of boiling point 65° C./0.4 mbar, nD20 =1.4580, were obtained.

Aufarbeitung

distillationAfter distillation over a Vigreux column, 198.7 g (72% of theory) of methyl 3-pyrrolidinovalerate of boiling point 65° C./0.4 mbar
customnD20 =1.4580, were obtained

Quellen und Nachweise

ORD-Eintrag: ord-8c83315f67fe41fc94a1e1befc7c9c9c
Quelldatensatz: uspto-grants-1988_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04791220

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