Sulfuric Acid → 2,3-Dichloro-4,5-difluorobenzamide

HRID 414365Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 414365
[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([F:11])[C:7]([F:12])=[CH:6][C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:14]>>[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([F:11])[C:7]([F:12])=[CH:6][C:3]=1[C:4]([NH2:5])=[O:14]

Komponenten

3

Edukt 2

HCID 1118Sulfuric AcidHCID 140963672,3-Dichloro-4,5-difluorobenzonitrile

Produkt 1

HCID 140963682,3-Dichloro-4,5-difluorobenzamide

Versuchsvorschrift

A solution of 2,3-dichloro-4,5-difluorobenzonitrile (1.0 g) in concentrated sulfuric acid (2.5 ml) was stirred at 90° to 100° C. for 30 minutes and then cooled. The residue was poured into ice water and the resulting precipitate was collected by filtration and recrystallized from benzene to give the title compound (0.51 g) as colorless needles, mp 153°-155° C.

Aufarbeitung

  1. temperaturecooled
  2. filtrationthe resulting precipitate was collected by filtration
  3. customrecrystallized from benzene

Quellen und Nachweise

ORD-Eintrag
ord-daf80a6adebf416a8087b9e7fc30cb5e
Quelldatensatz
uspto-grants-1988_12
Patentnummer
US04791225

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