N-Methylol-alpha-chloroacetamide → 4-Methyl-6-alpha-chloroacetylaminomethyl-7-hydroxy-1-indanone

HRID 414674

Reaktionsgleichung

Reaktionsgleichung von HRID 414674
[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12].O[CH2:14][NH:15][C:16](=[O:19])[CH2:17][Cl:18]>S(=O)(=O)(O)O>[CH3:1][C:2]1[CH:10]=[C:9]([CH2:14][NH:15][C:16](=[O:19])[CH2:17][Cl:18])[C:8]([OH:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12]

Komponenten

4

Edukt 2

HCID 62466N-Methylol-alpha-chloroacetamideHCID 124362447-Hydroxy-4-methyl-1-indanone

Produkt 1

HCID 136041414-Methyl-6-alpha-chloroacetylaminomethyl-7-hydroxy-1-indanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

9.3 Grams of 4-methyl-7-hydroxy-1-indanone and 30 g of N-hydroxymethyl-α-chloroacetamide were dissolved by adding 280 ml of concentrated sulfuric acid under a cooling condition. After the mixture was allowed to stand overnight, the mixture was poured into ice-water. The crystals formed in the mixture were collected by filtration and were recrystallized from ethanol to obtain 49 g of 4-methyl-6-α-chloroacetylaminomethyl-7-hydroxy-1-indanone.

Aufarbeitung

  1. customThe crystals formed in the mixture
  2. filtrationwere collected by filtration
  3. customwere recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-4a7e1f9656b248dd9a61a3d930cddd9f
Quelldatensatz
uspto-grants-1988_12
Patentnummer
US04792628

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