Chlorosulfonic acid → 4-(2,2,2-Trifluoroacetamido)benzene-1-sulfonyl chloride

HRID 414787Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 414787
[Cl:1][S:2]([OH:5])(=O)=[O:3].[F:6][C:7]([F:18])([F:17])[C:8]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:9]>>[F:6][C:7]([F:17])([F:18])[C:8]([NH:10][C:11]1[CH:16]=[CH:15][C:14]([S:2]([Cl:1])(=[O:5])=[O:3])=[CH:13][CH:12]=1)=[O:9]

Komponenten

3

Edukt 2

HCID 24638Chlorosulfonic acidHCID 678812,2,2-Trifluoro-N-phenylacetamide

Produkt 1

HCID 212805824-(2,2,2-Trifluoroacetamido)benzene-1-sulfonyl chloride

Versuchsvorschrift

Chlorosulfonic acid (100 g.) was cooled to 0° C. and trifluoroacetanilide (30 g.) was added portionwise with vigorous stirring keeping the temperature below +5° C. The reaction was stirred at room temperature overnight, and cautiously poured onto ice. The white solid produced was filtered, washed copiously with water, and dried to give 4-trifluoroacetamido benzenesulfonyl chloride (39.14 gl)(m.r. 143°-146° C.).

Aufarbeitung

  1. customthe temperature below +5° C
  2. stirringThe reaction was stirred at room temperature overnight
  3. additioncautiously poured onto ice
  4. customThe white solid produced
  5. filtrationwas filtered
  6. washwashed copiously with water
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ed5937b650f7415296cb11e2862453de
Quelldatensatz
uspto-grants-1988_12
Patentnummer
US04794196

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