2-(Bromomethyl)quinoline → 2-[3-(1-Hydoxyhexyl) anilinomethyl]quinoline
Reaktionsgleichung
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11]Br.[OH:13][CH:14]([C:20]1[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=1)[NH2:23])[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>>[OH:13][CH:14]([C:20]1[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=1)[NH:23][CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:1]=1)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]Komponenten
3
Versuchsvorschrift
For compounds in which X is --NR2 --(CHR1)n --, the corresponding amino starting compounds are employed to form the desired amino coppound. Thus, 2-aminopyridine is condensed with 3-(1-hydroxyhexyl)benzyloromide to form 2-[3-(1-hydroxyhexyl)benzylamino]pyridine. Alternatively, 2-quinolylmethylbromide is condensed with 3-(1-hydroxyhexyl)aniline to form 2-[3-(1-hydoxyhexyl) anilinomethyl]quinoline.
Quellen und Nachweise
- ORD-Eintrag
- ord-fa4e0d4a798d4b82be9cdf36505807de
- Quelldatensatz
- uspto-grants-1988_12