2,4,5,6-Tetrachloropyrimidine → HCID 178493073, Verbindung

HRID 415441

Reaktionsgleichung

Reaktionsgleichung von HRID 415441
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([Cl:9])=[C:4](Cl)[N:3]=1.Cl.[CH3:12][O:13][C:14]1[NH:18][N:17]=[C:16]([NH2:19])[CH:15]=1>C(O)C>[Cl:1][C:2]1[N:3]=[C:4]([NH:19][C:16]2[CH:15]=[C:14]([O:13][CH3:12])[NH:18][N:17]=2)[C:5]([Cl:9])=[C:6]([Cl:8])[N:7]=1

Komponenten

4

Edukt 2

HCID 156902,4,5,6-TetrachloropyrimidineHCID 178493289HCID 178493289, Verbindung

Produkt 1

HCID 178493073HCID 178493073, VerbindungAusbeute 25,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 2,4,5,6-tetrachloro-pyrimidine (2.18 g) in absolute ethanol (100 mL) was added DIEPA (4.4 mL) and 5-methoxy-1H-pyrazol-3-amine hydrogen chloride salt (1.50 g). The resulting solution was stirred at room temperature for over night. The solvent was evaporated under reduced pressure. The crude compound was purified by Gilson (10-60% MeCN/H2O, 15 minutes) to give the titled compound as solid (0.76 g). m/z 294.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. customThe crude compound was purified by Gilson (10-60% MeCN/H2O, 15 minutes)

Quellen und Nachweise

ORD-Eintrag
ord-31b3bb9ac5eb443390e029345ae3ca5f
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08088784B2

Verknüpfte Notizen

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