Sulfuric acid magnesium salt (1:1) → tert-Butyl 4-{[(3-amino-2-chloroquinolin-4-yl)amino]methyl}benzylcarbamate

HRID 415478Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 415478
[Cl:1][C:2]1[C:11]([N+:12]([O-])=O)=[C:10]([NH:15][CH2:16][C:17]2[CH:31]=[CH:30][C:20]([CH2:21][NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[CH:19][CH:18]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.S([O-])([O-])(=O)=O.[Mg+2]>>[NH2:12][C:11]1[C:2]([Cl:1])=[N:3][C:4]2[C:9]([C:10]=1[NH:15][CH2:16][C:17]1[CH:31]=[CH:30][C:20]([CH2:21][NH:22][C:23](=[O:29])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])=[CH:19][CH:18]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2

Komponenten

3

Edukt 2

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 86633725Tert-butyl 4-{[(2-chloro-3-nitroquinolin-4-yl)amino]methyl}benzylcarbamate

Produkt 1

HCID 86633726tert-Butyl 4-{[(3-amino-2-chloroquinolin-4-yl)amino]methyl}benzylcarbamateAusbeute 96,9 %

Versuchsvorschrift

The method of Part B of Example 1 was used to hydrogenate tert-butyl 4-{[(2-chloro-3-nitroquinolin-4-yl)amino]methyl}benzylcarbamate (20 g, 45 mmol) with the modification that magnesium sulfate was added to the mixture before filtration. tert-Butyl 4-{[(3-amino-2-chloroquinolin-4-yl)amino]methyl}benzylcarbamate (18 g) was isolated as a thick, orange-red oil.

Aufarbeitung

  1. additionwas added to the mixture before filtration

Quellen und Nachweise

ORD-Eintrag
ord-441c3915a4e44582be7012d0ee7580f0
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08088790B2

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