N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide → 3-Amino-N-(4-cyano-3-trifluoromethyl-phenyl)-2-hydroxy-2-methyl-propionamide

HRID 415965Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 415965
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([C:12]2([CH3:15])[CH2:14][O:13]2)=[O:11])=[CH:5][C:4]=1[C:16]([F:19])([F:18])[F:17])#[N:2].[NH3:20].CO>>[NH2:20][CH2:14][C:12]([OH:13])([CH3:15])[C:10]([NH:9][C:6]1[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[C:4]([C:16]([F:19])([F:18])[F:17])[CH:5]=1)=[O:11]

Komponenten

3

Edukt 2

HCID 10149314N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamideHCID 21705897Ammonia methanol

Produkt 1

HCID 666202513-Amino-N-(4-cyano-3-trifluoromethyl-phenyl)-2-hydroxy-2-methyl-propionamide

Versuchsvorschrift

2-Methyl-oxirane-2-carboxylic acid (4-cyano-3-trifluoromethyl-phenyl)-amide (1.0 g, 3.48 mmoL) was dissolved in 7N NH3/MeOH solution (10 mL) at room temperature. The reaction mixture was stirred overnight and the solvent was removed to yield the title compound as pale yellow solid.

Aufarbeitung

  1. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-9596a80a7b8b4adb9a1190940e467ea3
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08088811B2

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