Acetylpyrazine → 4-((4-(1H-pyrazol-5-yl)pyrimidin-2-ylamino)methyl)-N-(2-aminophenyl)benzamide
Reaktionsgleichung
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:30])[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH:17][C:18]2[N:23]=[C:22]([C:24]3C=NC=C[N:25]=3)[CH:21]=[CH:20][N:19]=2)=[CH:12][CH:11]=1.[N:31]1C=CN=[CH:33][C:32]=1C(=O)C.N1NC(C(=O)C)=CC=1>>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:30])[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH:17][C:18]2[N:23]=[C:22]([C:24]3[NH:25][N:31]=[CH:32][CH:33]=3)[CH:21]=[CH:20][N:19]=2)=[CH:12][CH:11]=1Komponenten
4
Versuchsvorschrift
Title compound was obtained according to the scheme 6 similarly to the compound 26a (Example 29) using instead of 1-pyrazin-2-yl-ethanone as the starting material 1-(2H-pyrazol-3-yl)-ethanone (Table 11). Characterization of the title compound is provided in the Table 12.
Quellen und Nachweise
- ORD-Eintrag
- ord-006aa4a1013c4723905c098b855d4c77
- Quelldatensatz
- uspto-grants-2012_01
- Patentnummer
- US08088805B2
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