Acetylpyrazine → (E)-1-[2-(bis-Boc-Amino)-4-methylthiazol-5-yl]-3-(dimethylamino)prop-2-en-1-one

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Acetylpyrazine	HCID 30914	—
Edukt	(E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-one	HCID 5825354	—
Edukt	2-(Bis-boc-amino-)-5-acetyl-4-methylthiazole	HCID 58930550	—
Produkt	(E)-1-[2-(bis-Boc-Amino)-4-methylthiazol-5-yl]-3-(dimethylamino)prop-2-en-1-one	HCID 58930666	16%

Reaktionsschritte

Following the procedure described for the synthesis of enamino ketone 23a (scheme 6) but substituting 1-(pyrazin-2-yl)-ethanone for the ketone 336, title compound was obtained in 16% yield. 1H NMR (DMSO-d6) δ (ppm): 7.65 (d, J=12.1 Hz, 1H), 5.34 (d, J=12.1 Hz, 1H), 3.14 (s, 3H), 2.87 (s, 3H), 2.50 (s, 3H), 1.51 (s, 18H). MS (m/z): 411.52 (calc) 412.3 (MH+) (found).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08088805B2
Quelldatensatz	uspto-grants-2012_01
ORD ID	ord-c956263b7c384a57a63663a6c4026410
Quellennotiz	uspto-grants-2012_01