4-(4-(Pyridin-3-yl)pyrimidin-2-ylamino)benzoic acid → 4-(4-(Pyridin-3-yl)pyrimidin-2-ylamino)-N-(2-aminophenyl)benzamide

HRID 416284Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 416284
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:30])[C:10]1[CH:15]=[CH:14][C:13](CNC2N=C(C3C=NC=CN=3)C=CN=2)=[CH:12][CH:11]=1.[N:31]1[CH:36]=[CH:35][CH:34]=[C:33]([C:37]2[CH:42]=[CH:41][N:40]=[C:39]([NH:43]C3C=CC(C(O)=O)=CC=3)[N:38]=2)[CH:32]=1>>[N:31]1[CH:36]=[CH:35][CH:34]=[C:33]([C:37]2[CH:42]=[CH:41][N:40]=[C:39]([NH:43][C:13]3[CH:12]=[CH:11][C:10]([C:9]([NH:8][C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=4[NH2:1])=[O:30])=[CH:15][CH:14]=3)[N:38]=2)[CH:32]=1

Komponenten

3

Edukt 2

HCID 143469704-(4-(Pyridin-3-yl)pyrimidin-2-ylamino)benzoic acidHCID 44570891N-(2-aminophenyl)-4-((4-(pyrazin-2-yl)pyrimidin-2-ylamino)methyl)benzamide

Produkt 1

HCID 445713334-(4-(Pyridin-3-yl)pyrimidin-2-ylamino)-N-(2-aminophenyl)benzamide

Versuchsvorschrift

Title compound was obtained in 54% yield according to the procedure described for the synthesis of compound 26a (scheme 6, step 4) replacing acid 25a by the acid 343. Characterization of the title compound is provided in the Table 12.

Quellen und Nachweise

ORD-Eintrag
ord-192d742e1ed242a5bb2c2566d7bb63df
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08088805B2

Notizen zur Reaktion

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