1-(4-Fluorobenzyl)piperazine → 5-Bromo-4-(4-(4-fluorobenzyl)piperazin-1-yl)-3-nitropyridin-2-amine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

1-(4-Fluorobenzyl)piperazine (0.160 g, 0.81 mmol, 1.05 eq) was suspended in iPrOH (8 mL) and DIPEA (0.72 mL). To this solution, the 5-bromo-4-chloro-3-nitropyridin-2-amine (0.19 g, 0.77 mmol, 1 eq) was added and the reaction mixture was heated and stirred for 17 h at 60° C. The mixture was filtered, washed with iPrOH (3×3 mL), Et2O (2×3 mL) and dried to give the title compound as a bright yellow solid (0.250 g, 75%); 1H-NMR (500 MHz, DMSO-d6): δ 2.43-2.55 (m, 4H, piperazine N(CH2)2), 3.05 (m, 4H, piperazine N(CH2)2), 3.51 (s, 2H, NCH2), 6.96 (br s, 2H, NH2), 7.14 (t, J=9.0 Hz, 2H, ArH), 7.35 (dd, J=8.5, 6.0 Hz, 2H, ArH), 8.15 (s, 1H, pyridine 6-H). LC (Method B)-MS (ESI, m/z): Rt=2.52 min—410/412 [(M+H+), Br isotopic pattern, 100%].

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