Sodium Hydroxide → HCID 46928985, Verbindung
Reaktionsgleichung
C([O:3][C:4](=[O:50])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:23]=[C:24]([C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([F:42])[CH:37]=3)[CH:25]=[C:26]([O:28][CH2:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:27]=2)[C:10]=1[CH2:43][CH2:44][C:45]([O:47]CC)=[O:46])C.[OH-].[Na+]>>[CH2:29]([O:28][C:26]1[CH:27]=[C:22]([O:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][C:11]2[C:10]([CH2:43][CH2:44][C:45]([OH:47])=[O:46])=[C:9]([CH:14]=[CH:13][CH:12]=2)[O:8][CH2:7][CH2:6][CH2:5][C:4]([OH:50])=[O:3])[CH:23]=[C:24]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([F:42])[CH:37]=2)[CH:25]=1)[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1Komponenten
3
Versuchsvorschrift
A similar procedure as described in Example 43, step 5 was used, starting from 4-[3-[6-(5-benzyloxy-3′-fluoro-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (229 mg, 0.34 mmol) and 1.0 N aqueous sodium hydroxide (5 mL) to afford 4-[3-[6-(5-benzyloxy-3′-fluoro-biphenyl-3-yloxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (163 mg, 78%) as an amorphous white solid: ES(+)-HRMS m/e calcd for C38H41FO7 (M+Na)+ 651.2728. found 651.2729.
Quellen und Nachweise
- ORD-Eintrag
- ord-f4f3f509356845b1b0a9cb01e541dc84
- Quelldatensatz
- uspto-grants-2012_01