Methyl chloroformate → (S)-benzyl 4-(difluoromethoxy)-2-(methoxycarbonylamino)butanoate

HRID 417662Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 417662
[NH2:1][C@@H:2]([CH2:13][CH2:14][O:15][CH:16]([F:18])[F:17])[C:3]([O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:4].[CH3:19][O:20][C:21](Cl)=[O:22]>ClCCl>[F:18][CH:16]([F:17])[O:15][CH2:14][CH2:13][C@H:2]([NH:1][C:21]([O:20][CH3:19])=[O:22])[C:3]([O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:4]

Komponenten

4

Edukt 2

HCID 6586Methyl chloroformateHCID 67991507(S)-benzyl 2-amino-4-(difluoromethoxy)butanoate

Produkt 1

HCID 59610623(S)-benzyl 4-(difluoromethoxy)-2-(methoxycarbonylamino)butanoateAusbeute 40 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

(S)-Benzyl 2-amino-4-(difluoromethoxy)butanoate (116 mg, 0.448 mmol) was dissolved in anhydrous dichloromethane (2.5 mL) and cooled down to 0° C. and TEA (181 mg, 1.79 mmol) and methylchloroformate (51 mg, 0.538 mmol) were added respectively. The mixture was stirred for 30 minutes and then it was stirred at room temperature overnight. The resulting product mixture was quenched with saturated NaHCO3 and extracted with dichloromethane. The organic layer was washed with saturated NH4Cl solution and brine and dried over Na2SO4. The volatiles were removed in vacuo to afford 56 mg (40%) of desired product after column purification.

Aufarbeitung

  1. stirringit was stirred at room temperature overnight
  2. customThe resulting product mixture was quenched with saturated NaHCO3
  3. extractionextracted with dichloromethane
  4. washThe organic layer was washed with saturated NH4Cl solution and brine
  5. dry with materialdried over Na2SO4
  6. customThe volatiles were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-62b426d4febe4ea68f6f2a9766510c94
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08088368B2

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