Methylamine → N-methyl-4-(pent-4-ynyl)piperazine-1-carboxamide

HRID 417866Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 417866
[CH2:1]([N:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14]C2C=CC([N+]([O-])=O)=CC=2)=O)[CH2:8][CH2:7]1)[CH2:2][CH2:3][C:4]#[CH:5].[CH3:24][NH2:25]>C1COCC1>[CH3:24][NH:25][C:12]([N:9]1[CH2:8][CH2:7][N:6]([CH2:1][CH2:2][CH2:3][C:4]#[CH:5])[CH2:11][CH2:10]1)=[O:14]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 866082224-Nitrophenyl 4-(pent-4-ynyl)piperazine-1-carboxylate

Produkt 1

HCID 86608223N-methyl-4-(pent-4-ynyl)piperazine-1-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 4-nitrophenyl 4-(pent-4-ynyl)piperazine-1-carboxylate (1.37 g) in THF (10 mL) was treated with 40% aq. MeNH2 (10 mL) at 70 C for 2 h. The mixture was concentrated and diluted with conc. NH4OH (5 mL) and water (15 mL). Extraction (DCM, 80 mL) and concentration gave N-methyl-4-(pent-4-ynyl)piperazine-1-carboxamide (0.659 g).

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. additiondiluted with conc. NH4OH (5 mL) and water (15 mL)
  3. extractionExtraction (DCM, 80 mL) and concentration

Quellen und Nachweise

ORD-Eintrag
ord-0edfe2919b6240f0adf1ea6e6ad2e6ce
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093229B2

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