Sodium Hydroxide → Sodium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

Methyl (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxylate (1.00 g, 6.2 mmol) was dissolved in 80% aqueous 1,4-dioxane. 1.2 M aqueous NaOH solution was added (5.2 ml) and the reaction mixture was stirred at room temperature for 3 h. After that the solvents were removed under reduced pressure and a colourless solid was obtained (1.03 g, 6.1 mmol, 98%). The product was used immediately in the next reaction step without further purification.

1. customAfter that the solvents were removed under reduced pressure
2. customa colourless solid was obtained (1.03 g, 6.1 mmol, 98%)
3. customThe product was used immediately in the next reaction step without further purification

ORD-Eintrag

ord-e767e90f8e1a4ff1abfe3845590f2a4a

Quelldatensatz

uspto-grants-2013_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08535655B2