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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 418424Erstellt: 26. Oktober 2026

2,5-Dimethyl-1H-indole → 8-Methyl-(2,5-dimethyl-1H-indol-3-yl)quinoline

https://huagongshe.com/reaction/418424

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt2,5-Dimethyl-1H-indoleHCID 70965—
Edukt4-Chloro-8-methylquinolineHCID 12326335—
LösungsmittelDiethyl EtherHCID 3283—
LösungsmittelN-methyl-2-pyrrolidoneHCID 13387—
Produkt8-Methyl-(2,5-dimethyl-1H-indol-3-yl)quinolineHCID 1872947999,7%

Reaktionsbedingungen

Temperatur140 °C

Reaktionsschritte

2,5-Dimethylindole (290 mg) and 8-methyl-4-chloroquinoline (360 mg) were suspended in N-methylpyrolidinone (0.5 ml), and maintained under a nitrogen atmosphere. The reaction was heated to 140° C. with stirring for 45 minutes. On cooling a deep red precipitate formed, the mixture was diluted with diethylether and the solid collected by filtration, and dried to give the sub-title compound (570 mg).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08093278B2
Quelldatensatzuspto-grants-2012_01
ORD IDord-ae91cbb6e53f482bb788d4d9733ac7db
Quellennotizuspto-grants-2012_01