HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 418428Erstellt: 25. Oktober 2026
2,5-Dimethyl-1H-indole → 4-(2,5-Dimethyl-1H-indol-3-yl)-8-(trifluoromethyl)-quinoline, hydrochloride
https://huagongshe.com/reaction/418428
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 2,5-Dimethyl-1H-indole | HCID 70965 | — |
| Edukt | 4-Chloro-8-(trifluoromethyl)quinoline | HCID 90262 | — |
| Lösungsmittel | Hydrochloric Acid | HCID 313 | — |
| Lösungsmittel | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | 4-(2,5-Dimethyl-1H-indol-3-yl)-8-(trifluoromethyl)-quinoline, hydrochloride | HCID 131729345 | 67% |
Reaktionsschritte
A mixture of 2,5-dimethylindole (765 mg) and 4-chloro-8-trifluoromethylquinoline (1.22 g) in NMP (1.5 ml) and 4M HCl in dioxane (0.2 ml) was heated at 140° C. for 1 h. After cooling the mixture was triturated with ether and filtered to give the sub-title compound (1.33 g) as a dark red solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08093278B2 |
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| Quelldatensatz | uspto-grants-2012_01 |
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| ORD ID | ord-3d83c96dcd864fa89b3975550fedd3df |
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| Quellennotiz | uspto-grants-2012_01 |
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