Sodium Hydroxide → HCID 10046404, Verbindung
Reaktionsgleichung
[CH3:1][C:2]1[N:3]([CH2:26][C:27]([O:29]CC)=[O:28])[C:4]2[C:9]([C:10]=1[C:11]1[C:20]3[C:15](=[C:16]([C:21]([F:24])([F:23])[F:22])[CH:17]=[CH:18][CH:19]=3)[N:14]=[CH:13][CH:12]=1)=[CH:8][C:7]([CH3:25])=[CH:6][CH:5]=2.[OH-].[Na+]>C1COCC1.CO>[CH3:1][C:2]1[N:3]([CH2:26][C:27]([OH:29])=[O:28])[C:4]2[C:9]([C:10]=1[C:11]1[C:20]3[C:15](=[C:16]([C:21]([F:22])([F:23])[F:24])[CH:17]=[CH:18][CH:19]=3)[N:14]=[CH:13][CH:12]=1)=[CH:8][C:7]([CH3:25])=[CH:6][CH:5]=2Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of product from step b) (1.46 g) and 1 M sodium hydroxide (3.42 ml) in THF (20 ml) and methanol (2 ml) was stirred for 16 hours. The solvent was removed in vacuo and the residue was dissolved in water (20 ml) and washed with dichloromethane. 1M HCl (3.4 ml) was added slowly to the stirred solution. The precipitate was collected and dried to give the title compound (1.23 g. M.p. 145° C.